abstract：PURPOSE:We applied Multi-Criteria Decision Analysis (MCDA) methods in a structured benefit-risk assessment of cladribine and newer approved disease-modifying drugs (DMDs) for patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Decision conferencing with clinical neurologists as decision makers was use...

journal_title：Clinical therapeutics

authors： Vermersch P,Martinelli V,Pfleger C,Rieckmann P,Alonso-Magdalena L,Galazka A,Dangond F,Phillips L

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Therapy for patients with type 2 diabetes (T2DM) not achieving hemoglobin (Hb) A1c targets may progress from an oral antidiabetic drug (OAD) to added basal insulin and then to multiple daily injections of basal-bolus insulin (MDI); however, the relative clinical and economic burden experienced by patients presc...

journal_title：Clinical therapeutics

authors： Brixner D,Ermakova A,Xiong Y,Sieradzan R,Sacks N,Cyr P,Taylor SD

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Prostate cancer is the second most common cancer among men worldwide. In the past 10 years in Iran, prostate cancer has increased and become more common among hormone-related cancers. As the percentage of seniors in the population increases, the economic burden of this cancer will likely increase significantly....

journal_title：Clinical therapeutics

authors： Mojahedian MM,Toroski M,Keshavarz K,Aghili M,Zeyghami S,Nikfar S

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with several potential health benefits, but standard ethyl ester (EE) formulations of these ω-3 fatty acids require the co-ingestion of fat for adequate absorption. The objective of this research was to assess the relative bioa...

journal_title：Clinical therapeutics

authors： Maki KC,Palacios OM,Buggia MA,Trivedi R,Dicklin MR,Maki CE

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The goal of this study was to evaluate clinical outcomes and patient-reported outcomes (PROs) over 12 months in patients with relapsing multiple sclerosis (RMS) who switched from glatiramer acetate (GA) to delayed-release dimethyl fumarate (DMF) 240 mg BID after suboptimal response to GA in real-world clinical ...

journal_title：Clinical therapeutics

authors： Kresa-Reahl K,Repovic P,Robertson D,Okwuokenye M,Meltzer L,Mendoza JP

更新日期：2018-12-01 00:00:00

abstract：:The history of drug safety monitoring, or pharmacovigilance, has been an interesting one. Despite many and ongoing changes, it has typically been characterized by a rather slow-moving and reactive progression. Pharmacovigilance has always lagged behind other fields and industries and has been slow to adapt to new appr...

journal_title：Clinical therapeutics

authors： Streefland MB

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:ME-401 is a novel selective inhibitor of phosphatidylinositol 3 kinase p110δ, an enzyme often found overexpressed and overactive in B-cell malignancies. The current study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending oral doses of ME-401 in healthy ...

journal_title：Clinical therapeutics

authors： Moreno O,Butler T,Zann V,Willson A,Leung P,Connor A

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Respiratory syncytial virus (RSV) and influenza are important viral pathogens worldwide. Children, in particular, bear considerable burdens of morbidity and mortality associated with these viruses. There are limited therapeutic options for children infected with RSV or influenza. This review focuses on therapeu...

journal_title：Clinical therapeutics

authors： Nicholson EG,Munoz FM

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:This article focuses on 10 case studies of companies/organizations that are part of the current innovation ecosystem of regenerative medicine (RM) in the United Kingdom. It analyzes the actors, linkages, and influences that will determine the future shape of the RM industry sector and its capacity to live up to...

journal_title：Clinical therapeutics

authors： Banda G,Tait J,Mittra J

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:The effects of air pollutants have been receiving increased attention both clinically and in the media. One such pollutant is mold, fungal growth in the form of multicellular filaments known as hyphae. The growth of molds is omnipresent not only in outdoor settings but also in indoor environments containing exc...

journal_title：Clinical therapeutics

authors： Ratnaseelan AM,Tsilioni I,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The purposes of this review are to describe the pathogenesis of mucormycosis and to address recent research advances in understanding the mechanisms of fungal invasion and dissemination. METHODS:Studies and reviews published in the PubMed and ClinicalTrials.gov databases until December 2017 that explored or re...

journal_title：Clinical therapeutics

authors： Petrikkos G,Tsioutis C

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Methylphenidate hydrochloride extended-release chewable tablet (MPH ERCT) is approved for treatment of attention deficit hyperactivity disorder in patients aged 6 years and older. This article evaluates the pharmacokinetic parameters and relative bioavailability of MPH ERCT when chewed versus swallowed whole. ...

journal_title：Clinical therapeutics

authors： Abbas R,Childress AC,Nagraj P,Rolke R,Berry SA,Palumbo DR

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Hypertension and dyslipidemia are 2 risk factors of cardiovascular disease that often present simultaneously. Traditionally, treatment of these multiple conditions required separate medications for each disease, which may result in poor compliance and thus lead to possible treatment failure. Fixed-dose combinat...

journal_title：Clinical therapeutics

authors： Oh GC,Han JK,Han KH,Hyon MS,Doh JH,Kim MH,Jeong JO,Bae JH,Kim SH,Yoo BS,Baek SH,Rhee MY,Ihm SH,Sung JH,Choi YJ,Kim SJ,Hong KS,Lee BK,Cho J,Shin ES,Rhew JY,Kim H,Kim HS

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The comparative efficacy of endocrine-based therapies (ETs) for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) is not well characterized. This network meta-analysis (NMA) synthesized available evidence on progression-free survival (PFS) wit...

journal_title：Clinical therapeutics

authors： Ayyagari R,Tang D,Patterson-Lomba O,Zhou Z,Xie J,Chandiwana D,Dalal AA,Niravath PA

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:This was a prospective observational cohort study that aimed to determine whether fetal sex influences the maternal and fetal outcomes of gestational diabetes mellitus (GDM). METHODS:In this study, 327 European primiparous women were consecutively recruited after diagnosis of GDM. AUC on the oral glucose toler...

journal_title：Clinical therapeutics

authors： Giannubilo SR,Pasculli A,Ballatori C,Biagini A,Ciavattini A

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:This observational study of oncologic clinical practices was designed to describe real-world patterns of use of emerging therapies (abiraterone acetate, cabazitaxel, enzalutamide, radium-223, sipuleucel-T) in patients with castration-resistant prostate cancer and to characterize their concomitant use with denos...

journal_title：Clinical therapeutics

authors： Liede A,Wade S,Lethen J,Hernandez RK,Warner D,Abernethy AP,Finelli A

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Our aim was to develop and validate the extrapolative performance of a regression model using a limited sampling strategy for accurate estimation of the area under the plasma concentration versus time curve for saroglitazar. METHODS:Healthy subject pharmacokinetic data from a well-powered food-effect study (fa...

journal_title：Clinical therapeutics

authors： Joshi SN,Srinivas NR,Parmar DV

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:New therapies, including daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd), have recently been approved in the United States for patients with multiple myeloma (MM) who have received at least 1 prior line of therapy. However, few treatments have been...

journal_title：Clinical therapeutics

authors： Maiese EM,Ainsworth C,Le Moine JG,Ahdesmäki O,Bell J,Hawe E

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:This study was designed to evaluate the safety and pharmacokinetic profiles of MRX-I tablet, an oxazolidinone antibacterial agent, in healthy Chinese subjects. METHODS:The study was composed of 3 sequential periods. Period 1 was a randomized, double-blind, placebo-controlled, sequential ascending dose (50 to 1...

journal_title：Clinical therapeutics

authors： Wu X,Li Y,Zhang J,Zhang Y,Yu J,Cao G,Chen Y,Guo B,Shi Y,Huang J,Cao Y,Liu X,Wu J,Gordeev MF,Yuan H,Wang W

更新日期：2018-02-01 00:00:00

abstract：:It is generally understood that pain experience and opioid abuse have relied on male-dominated models. However, sex and gender play a role in both pain experience and opioid use disorder. Using the previously validated Texas Tech University Health Sciences Center Sex and Gender Specific Health PubMed Advanced Search T...

journal_title：Clinical therapeutics

authors： Koons AL,Rayl Greenberg M,Cannon RD,Beauchamp GA

更新日期：2018-02-01 00:00:00

abstract：:Patients with Parkinson's disease experience disabling non-motor symptoms, including autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for these symptoms are often ineffective or have intolerable side effects. Therefore, non-pharmacologic interventions are an attractive alternativ...

journal_title：Clinical therapeutics

authors： Amara AW,Memon AA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare the bioavailability between 2 milk thistle-containing dietary supplements, Product B and IsaGenesis, in healthy volunteers. METHODS:Bioavailability between Product B, originally formulated as a powdered capsule, and IsaGenesis, reformulated as a soft gel, were compared ...

journal_title：Clinical therapeutics

authors： Li WY,Yu G,Hogan RM,Mohandas R,Frye RF,Gumpricht E,Markowitz JS

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The decline of central nervous system (CNS) function is a hallmark characteristic of multiple sclerosis (MS) that can manifest as cognitive impairment. We believe that exercise represents a potential behavioral approach for counteracting the declines in CNS structure and associated function among persons with M...

journal_title：Clinical therapeutics

authors： Motl RW,Sandroff BM

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the bioavailability of hydroxyprogesterone caproate (HPC) administered as a subcutaneous injection in the back of the upper arm using a prefilled autoinjector syringe with a 27-gauge needle compared with standard intramuscular injection in the gluteus maximus using a 21...

journal_title：Clinical therapeutics

authors： Krop J,Kramer WG

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the efficacy and tolerability of a triple combination of amlodipine/losartan/rosuvastatin in patients with hypertension and hypercholesterolemia. METHODS:A randomized, multicenter, double-blind, placebo-controlled study was conducted. Eligible patients with hypertens...

journal_title：Clinical therapeutics

authors： Lee HY,Kim SY,Choi KJ,Yoo BS,Cha DH,Jung HO,Ryu DR,Choi JH,Lee KJ,Park TH,Oh JH,Kim SM,Choi JY,Kim KH,Shim J,Kim WS,Choi SW,Park DG,Song PS,Hong TJ,Rhee MY,Rha SW,Park SW

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings. The purpose of this review was to address this gap in o...

journal_title：Clinical therapeutics

authors： Pandolfi F,Franza L,Altamura S,Mandolini C,Cianci R,Ansari A,Kurnick JT

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Few studies have determined the benefits of pharmacist-run clinics within a tertiary institution, and specifically on their capability to improve clinical outcomes as well as reduce the cost of illness. This study was designed to investigate the effectiveness of a pharmacist-managed risk factor management clini...

journal_title：Clinical therapeutics

authors： Tan SH,Kng KK,Lim SM,Chan A,Loh JKK,Lee JY

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:While corticosteroids are relatively inexpensive and commonly used as treatment for a variety of conditions, long-term use is known to be associated with certain toxicities. Prior systematic reviews have revealed an increased risk for costly adverse events (AEs), including bone fracture, infection, and gastroin...

journal_title：Clinical therapeutics

authors： Rice JB,White AG,Scarpati LM,Wan G,Nelson WW

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the impact of a listed penicillin allergy on the time to first dose of antibiotic in a Veterans Affairs hospital. Additional clinical outcomes of patients with penicillin allergies were compared with those of patients without a penicillin allergy. METHODS:A retrospec...

journal_title：Clinical therapeutics

authors： Conway EL,Lin K,Sellick JA,Kurtzhalts K,Carbo J,Ott MC,Mergenhagen KA

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Selumetinib (AZD6244, ARRY-142886), an oral, potent, and highly selective mitogen-activated protein kinase 1/2 inhibitor with a short half-life, has shown activity across various tumor types. Before initiation of Phase III trials, the site, scale, and color (hypromellose shell from white [Phase II] to blue [Pha...

journal_title：Clinical therapeutics

authors： Tomkinson H,McBride E,Martin P,Lisbon E,Dymond AW,Cantarini M,So K,Holt D

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Our study evaluated adverse events of therapeutic failure (and specifically reduced duration of action) with the use of a branded product, Osmotic Release Oral System (OROS) methylphenidate, which is approved for the treatment of attention deficit/hyperactivity disorder, and a generic product (methylphenidate, ...

journal_title：Clinical therapeutics

authors： Park-Wyllie L,van Stralen J,Castillon G,Sherman SE,Almagor D

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease inhibitors lopinavir/ritonavir (Kaletra® [Abbott Laboratories, Chicago, Illinois]). Clinical reports indicate that some children readily accept the taste of Kaletra, whereas ot...

journal_title：Clinical therapeutics

authors： Mennella JA,Mathew PS,Lowenthal ED

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Opioid diversion, misuse, and abuse are rapidly growing problems in the United States; >60% of all drug overdose deaths involve an opioid. At least 49 states now have fully operational prescription drug monitoring programs (PDMPs) to support legitimate medical use of controlled substances; however, there is con...

journal_title：Clinical therapeutics

authors： Finnell JT,Twillman RK,Breslan SA,Schultz J,Miller L

更新日期：2017-09-01 00:00:00

abstract：:Hypoglycemia in people with insulin-treated type 2 diabetes can be a limiting factor for management and a barrier to optimizing glycemic control. Even mild episodes of hypoglycemia can affect an individual's quality of life, and fear of hypoglycemia can lead to underinsulinization. This article explores the prevalence...

journal_title：Clinical therapeutics

authors： Blumer I,Clement M

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:In critical burn patients, the pharmacokinetic parameters (absorption, distribution, metabolism, and excretion) of many classes of drugs, including antibiotics, are altered. The aim of this study was to compare 2 groups of burn patients undergoing treatment for health care-associated infections with and without...

journal_title：Clinical therapeutics

authors： Machado AS,Oliveira MS,Sanches C,Silva Junior CVD,Gomez DS,Gemperli R,Santos SRCJ,Levin AS

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Intensive blood pressure (BP) lowering is important for the treatment of hypertension; however, it has been a challenge to achieve target BP in many patients. The purpose of this study was to explore the optimal dosage of a fixed-dose combination of candesartan cilexetil (CAN) and amlodipine besylate (AML), by ...

journal_title：Clinical therapeutics

authors： Sohn IS,Kim CJ,Ahn T,Youn HJ,Jeon HK,Ihm SH,Cho EJ,Chung WB,Chae SC,Kim WS,Nam CW,Park SM,Choi JY,Kim YK,Hong TJ,Lee HY,Cho JH,Shin ES,Yoon JH,Yang TH,Jeong MH,Lee JH,Park JI

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The goal of this study was to assess and compare the potential clinical and economic value of emerging bone-forming agents using the only currently available agent, teriparatide, as a reference case in patients at high, near-term (imminent, 1- to 2-year) risk of osteoporotic fractures, extending to a lifetime h...

journal_title：Clinical therapeutics

authors： O'Hanlon CE,Parthan A,Kruse M,Cartier S,Stollenwerk B,Jiang Y,Caloyeras JP,Crittenden DB,Barron R

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:The goal of this study is to identify and compare all direct costs of intravenous and subcutaneous rituximab given to patients with diffuse large B-cell lymphoma in the Netherlands. METHODS:Using a prospective, observational, bottom-up microcosting study, we collected primary data on the direct medical costs o...

journal_title：Clinical therapeutics

authors： Mihajlović J,Bax P,van Breugel E,Blommestein HM,Hoogendoorn M,Hospes W,Postma MJ

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:External electric muscle stimulation (EMS) of the thigh muscles was found to reduce pain resulting from diabetic neuropathy (DN), a vascular complication of diabetes. This study investigated circulating hematopoietic stem cells (HSCs) after EMS treatment. Impaired function of HSCs and the subpopulation endothel...

journal_title：Clinical therapeutics

authors： Hidmark A,Spanidis I,Fleming TH,Volk N,Eckstein V,Groener JB,Kopf S,Nawroth PP,Oikonomou D

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:We examined the safety profile and usability of an integrated advanced robotic device and telecare system to promote medication adherence for elderly home-care patients. METHODS:There were two phases. Phase I aimed to verify under controlled conditions in a single nursing home (n = 17 patients) that no robotic...

journal_title：Clinical therapeutics

authors： Rantanen P,Parkkari T,Leikola S,Airaksinen M,Lyles A

更新日期：2017-05-01 00:00:00